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April 2026 Central America & Panama Canal Cruises
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Showing 1 - 10 of 60 Cruises
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10 Night Central America & Panama Canal Cruise from Colon, Panama
Royal Caribbean International Serenade of the Seas
Departure Port:
Colon, Panama
OCG Class
Mainstream
Cruises to: PUNTARENAS, COSTA RICA; PUERTO VALLARTA, MEXICO; LOS ANGELES, CALIFORNIA
Departing
Interior
Oceanview
Balcony
Suite
Apr 25, 2026
$337
$667
$1,353
-
Add to Compare
10 Night Central America & Panama Canal Cruise from Miami, FL
Oceania Cruises Insignia
Departure Port:
Miami, FL
OCG Class
Premium
Cruises to: COZUMEL; COSTA MAYA; BELIZE CITY; ROATAN; COLON; PANAMA CITY; PANAMA CITY
Departing
Interior
Oceanview
Balcony
Suite
Apr 14, 2026
$1,774
$2,074
$3,674
$5,674
Add to Compare
10 Night Central America & Panama Canal Cruise from Panama City, Panama
Oceania Cruises Insignia
Departure Port:
Panama City, Panama
OCG Class
Premium
Cruises to: CARTAGENA; ROATAN; COSTA MAYA; COZUMEL; MIAMI
Departing
Interior
Oceanview
Balcony
Suite
Apr 24, 2026
$303
$453
$1,253
$2,378
Add to Compare
10 Night Central America & Panama Canal Cruise from Panama City, Panama
Oceania Cruises Insignia
Departure Port:
Panama City, Panama
OCG Class
Premium
Cruises to: CARTAGENA; WILLEMSTAD; ORANJESTAD; MONTEGO BAY; GEORGE TOWN; MIAMI
Departing
Interior
Oceanview
Balcony
Suite
Apr 4, 2026
$1,994
$2,394
$3,894
$6,194
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
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